(2002) cloned UMP/CMP kinase. CMP can be phosphorylated to cytidine diphosphate by the enzyme CMP kinase, with adenosine triphosphate or guanosine triphosphate donating the phosphate group. Birth Defects Orig.
(Rh is located on 1p36.2-p34. [§ 1], 1udw: Crystal structure of human uridine-cytidine kinase 2 complexed with a feedback-inhibitor, CTP, 1uei: Crystal structure of human uridine-cytidine kinase 2 complexed with a feedback-inhibitor, UTP, 1uej: Crystal structure of human uridine-cytidine kinase 2 complexed with a substrate, cytidine, 1ufq: Crystal structure of ligand-free human uridine-cytidine kinase 2, 1uj2: Crystal structure of human uridine-cytidine kinase 2 complexed with products, CMP and ADP, 1xrj: Rapid structure determination of human uridine-cytidine kinase 2 using a conventional laboratory X-ray source and a single samarium derivative. The endogenous enzyme appeared as a single protein that comigrated with the 196-amino acid form expressed in transfected HeLa cells.
25: 9-20, 1979. 25: 39-57, 1977. The other UCK protein is uridine-cytidine kinase 1, which shares about 70% sequence identity with UCK2. [Full Text], Gallango, M. L., Muller, A., Suinaga, R. ATP + cytidine ⇌ ADP + CMP.. Cette enzyme intervient dans la biosynthèse de novo des nucléotides pyrimidiques.Le GTP et l'IMP peuvent servir de donneur de phosphate à la place de l'ATP.. Notes et références Furthermore, this role concerns only dCMP phosphorylation, a feature of this family of enzymes. No difference in levels of naturally acquired HIB anticapsular antibodies between persons with HIB disease and health controls was found. [Full Text], Ranzani, G., Bertolotti, E., Santachiara-Benerecetti, A. S. (1975) assigned UMPK to chromosome 1 by study of somatic cell hybrids. 279: 33882-33889, 2004. Biochem. , Deoxycytidylate kinase A new polymorphic enzyme, uridine monophosphate kinase: gene frequencies and a linkage analysis. 30: 215-218, 1978. [7] A magnesium ion is coordinated in the active site by Glu-135, Ser-34, and Asp-62. , cytidylate kinase The phosphorylation rate is significantly decreased when either of the two pentose interacting residues is mutated. [PubMed: 10462544, related citations] 52072 Aachen and the National Cancer Institute,
, mitochondrial UMP-CMP kinase , thymidylate kinase LPS-inducible member The polymorphism of the red cell uridine monophosphate kinase in two samples of the Italian population. 15: 146-152, 1975. Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates. Uridine-cytidine kinase 2 (UCK2) is an enzyme that in humans is encoded by the UCK2 gene. Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme. The polymorphism of the red cell uridine monophosphate kinase in two samples of the Italian population. Genet. This gene encodes one of the enzymes required for cellular nucleic acid biosynthesis. , UMP-CMP kinase 2-like Report of the committee on the genetic constitution of chromosome 1. Uridine monophosphate kinase polymorphism in two Venezuelan populations.
Ser. [PubMed: 2863446, related citations] Birth Defects Orig. Reducing agents activated UMP/CMP kinase in a dose-dependent manner. [Full Text: https://dx.doi.org/10.1159/000131394], Gallango, M. L., Muller, A., Suinaga, R. Cytidine Monophosphate (UMP-CMP) Kinase 2, Mitochondrial (CMPK2), Mast/stem Cell Growth Factor Receptor (KIT), Protein tyrosine Phosphatase, Receptor Type, C (PTPRC), V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1), Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2), BCL2-Associated Agonist of Cell Death (BAD), V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1), Amyloid beta (A4) Precursor Protein (APP), Platelet/endothelial Cell Adhesion Molecule (PECAM1), CD3e Molecule, epsilon (CD3-TCR Complex) (CD3E), Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1), Epithelial Cell Adhesion Molecule (EPCAM), C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1), Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1), Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), anti-Cytidine Monophosphate (UMP-CMP) Kinase 2, Mitochondrial (CMPK2) anticorps, anti-Cytidine Monophosphate (UMP-CMP) Kinase 2, Mitochondrial (CMPK2) (C-Term) anticorps, anti-Cytidine Monophosphate (UMP-CMP) Kinase 2, Mitochondrial (CMPK2) (AA 142-170), (Center) anticorps, anti-Cytidine Monophosphate (UMP-CMP) Kinase 2, Mitochondrial (CMPK2) (AA 142-170) anticorps, anti-Cytidine Monophosphate (UMP-CMP) Kinase 2, Mitochondrial (CMPK2) (AA 150-180), (Center), (Internal Region) anticorps, anti-Cytidine Monophosphate (UMP-CMP) Kinase 2, Mitochondrial (CMPK2) (AA 150-180), (Center), (Internal Region) anticorps (Alkaline Phosphatase (AP)), anti-Cytidine Monophosphate (UMP-CMP) Kinase 2, Mitochondrial (CMPK2) (AA 150-180), (Center), (Internal Region) anticorps (Biotin), anti-Cytidine Monophosphate (UMP-CMP) Kinase 2, Mitochondrial (CMPK2) (AA 150-180), (Center), (Internal Region) anticorps (HRP), anti-Cytidine Monophosphate (UMP-CMP) Kinase 2, Mitochondrial (CMPK2) (AA 150-180), (Center), (Internal Region) anticorps (APC), anti-Cytidine Monophosphate (UMP-CMP) Kinase 2, Mitochondrial (CMPK2) (AA 150-180), (Center), (Internal Region) anticorps (FITC), CMPK2 in Cellular Response to Molecule of Bacterial Origin, cytidine/uridine monophosphate kinase 2 (CMPK2) anticorps, cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial (cmpk2) anticorps, cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial (Cmpk2) anticorps, cytidine/uridine monophosphate kinase 2 (Cmpk2) anticorps, anti-Cytidine Monophosphate (UMP-CMP) Kinase 2, Mitochondrial Anticorps.
Press (pub.) [1] It is an ester of phosphoric acid with the nucleoside cytidine. 1988. 25: 39-57, 1977.
L'uridine cytidine kinase 2 est une phosphotransférase qui catalyse les réactions : ATP + uridine ⇌ ADP + UMP. donation now and again in the future. Cancer Res. Uridine monophosphate kinase 3: a genetic marker for susceptibility to Haemophilus influenzae type B disease. [Full Text], Cytogenetic location: 1p33 [PubMed: 172293, related citations] 56: 562-569, 1999. These interactions are lost with the poorer substrates AraCMP and 2',3'-dideoxy-CMP. Mutating Ser101 reduces CMP phosphorylation only moderately, but dramatically reduces dCMP phosphorylation. Studies determining the Michaelis-Menten kinetic parameters for these enzymes revealed that UCK2 had a four to sixfold higher binding affinity, faster maximal rates, and greater efficiencies for uridine and cytidine substrates than did UCK1. , dCMP kinase [10], Both uridine-cytidine kinases, however, plays a crucial role in the biosynthesis of the pyrimidine nucleotides that compose RNA and DNA. In bacteria, CMP kinase catalyses the transfer of a phosphoryl group from ATP to CMP or dCMP. [Full Text], Gallango, M. L., Suinaga, R. Cell Genet. Lancet 326: 417-418, 1985. 26: 627-635, 1974. Assignment of the gene for human uridine monophosphate kinase to chromosome 1 using somatic cell hybrid clone panels. Genet. One strategy for anti-cancer and anti-viral therapies involves using UCK2 to activate anti-tumor prodrugs through phosphorylation.
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